Emma Stone has starred alongside Andrew Garfield in multiple films, notably "The Amazing Spider-Man" series, where she played Gwen Stacy opposite Garfield's Peter Parker. Their on-screen chemistry was widely praised, leading to their collaboration in a second film. Additionally, they both appeared in the movie "The Amazing Spider-Man 2," further solidifying their connection through shared projects. Their professional relationship has been highlighted by their performances and the dynamic they bring to their roles, making Emma Stone the actress most closely associated with Garfield in terms of co-starring in more than one film.